Inflammatory bowel disease attacks quickly and makes patients miserable. Recently, British researchers found the key factors causing inflammatory bowel disease. Now let's take a look at the key factors caused by inflammatory bowel disease!
Recientemente, un equipo de investigación británico descubrió que una proteína llamada T-bet desempeña un papel importante en el mantenimiento del delicado equilibrio entre el sistema inmunitario intestinal y la flora intestinal. Los experimentos muestran que la eliminación de esta proteína puede provocar síntomas similares a los de la enfermedad inflamatoria intestinal humana (EII) en ratones. Por lo tanto, los investigadores creen que la forma en que la proteína afecta el sistema inmunitario intestinal puede usarse como una dirección de investigación y, finalmente, allanar el camino para el desarrollo de nuevos métodos para el tratamiento de la enfermedad inflamatoria intestinal. Los resultados relevantes de la investigación se publicaron en la edición en línea del último número de Journal of immunology.
Inflammatory bowel disease refers to ulcerative colitis and Crohn's disease. This disease is common in western countries, and the prevalence rate in China has also begun to rise sharply in recent years. The etiology of inflammatory bowel disease is still unclear, but most studies have targeted the intestinal immune system. A large number of bacteria are parasitic in the human intestine, which plays an important role in maintaining human health. Under normal circumstances, the intestinal immune system will not respond to the activities of beneficial bacteria in the intestine, but only play a role when the internal balance is destroyed. The intestinal immune system of patients with inflammatory bowel disease is different. It will make an immune response to the beneficial flora in the intestine, leading to chronic inflammation.
In a research project funded by the British Medical Research Council and the Wellcome foundation, the research team led by Professor Graham Lord of King's College London found that a protein called T-bet has a strong influence on the interaction between cells of the intestinal immune system. The deletion of this protein will lead to the dysfunction of immune cells, cause inflammation and eventually lead to the occurrence of inflammatory bowel disease. Experiments have proved that once the T-bet protein in the mouse immune system is removed, it will lead to the symptoms similar to human inflammatory bowel disease in mice; Using these proteins as therapeutic targets can reverse the symptoms of inflammatory bowel disease in mice.
Los investigadores señalaron que su investigación es de gran importancia para confirmar por primera vez los procesos celulares y moleculares inmunitarios que pueden conducir a la enfermedad inflamatoria intestinal; La mejora de la proteína T-bet
